pI: 6.6225 |
Length (AA): 152 |
MW (Da): 17614 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There is 1 model calculated for this protein. More info on
this model, including the
model itself is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
3 | 80 | 4bbr (M) | 22 | 99 | 28.00 | 0.0000071 | 0.14 | 0.8608 | 1.12 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_127288)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT2G41630 | transcription initiation factor IIB-1 |
Arabidopsis thaliana | AT3G10330 | transcription initiation factor IIB-2 |
Babesia bovis | BBOV_II007500 | transcription initiation factor TFIIB, putative |
Brugia malayi | Bm1_51845 | Transcription initiation factor IIB |
Candida albicans | CaO19.3059 | one of two genes similar to S. cerevisiae SUA7 (YPR086W) RNA Pol II transcription factor TFIIB |
Candida albicans | CaO19.10577 | one of two genes similar to S. cerevisiae SUA7 (YPR086W) RNA Pol II transcription factor TFIIB |
Candida albicans | CaO19.3519 | one of two genes similar to S. cerevisiae SUA7 (YPR086W) RNA Pol II transcription factor TFIIB |
Caenorhabditis elegans | CELE_W03F9.5 | Protein TTB-1 |
Cryptosporidium parvum | cgd8_880 | transcription initiation factor TFIIB Sua7p; ZnR+2cyclins |
Dictyostelium discoideum | DDB_G0290929 | transcription initiation factor IIB |
Drosophila melanogaster | Dmel_CG5193 | Transcription factor IIB |
Echinococcus granulosus | EgrG_000898300 | transcription initiation factor TFIIB |
Entamoeba histolytica | EHI_050980 | hypothetical protein |
Echinococcus multilocularis | EmuJ_000898300 | transcription initiation factor TFIIB |
Homo sapiens | ENSG00000137947 | general transcription factor IIB |
Loa Loa (eye worm) | LOAG_09807 | transcription initiation factor IIB |
Mus musculus | ENSMUSG00000028271 | general transcription factor IIB |
Neospora caninum | NCLIV_012900 | At4g37010, related |
Oryza sativa | 4347689 | Os09g0534800 |
Onchocerca volvulus | OVOC12424 | Transcription initiation factor IIB homolog |
Plasmodium berghei | PBANKA_0202900 | transcription initiation factor TFIIB, putative |
Plasmodium falciparum | PF3D7_0110800 | transcription initiation factor TFIIB, putative |
Plasmodium knowlesi | PKNH_0203100 | transcription initiation factor TFIIB, putative |
Plasmodium vivax | PVX_081260 | transcription initiation factor TFIIB, putative |
Plasmodium yoelii | PY06502 | hypothetical protein |
Plasmodium yoelii | PY07322 | hypothetical protein |
Saccharomyces cerevisiae | YPR086W | Sua7p |
Schistosoma japonicum | Sjp_0303760 | ko:K03124 transcription initiation factor TFIIB, putative |
Schistosoma japonicum | Sjp_0064540 | Transcription initiation factor IIB, putative |
Schistosoma mansoni | Smp_063650.5 | transcription initiation factor iib |
Schistosoma mansoni | Smp_063650.3 | transcription initiation factor IIB (TFIIB) |
Schmidtea mediterranea | mk4.003891.00 | Putative transcription initiation factor iib |
Schmidtea mediterranea | mk4.005698.01 | Putative transcription initiation factor iib |
Schmidtea mediterranea | mk4.001961.03 | Putative transcription initiation factor iib |
Schmidtea mediterranea | mk4.035816.00 | Putative transcription initiation factor iib |
Schmidtea mediterranea | mk4.002511.00 | Putative transcription initiation factor iib |
Schmidtea mediterranea | mk4.013213.02 | Putative transcription initiation factor iib |
Schmidtea mediterranea | mk4.014344.00 | Putative transcription initiation factor iib |
Schmidtea mediterranea | mk4.047775.00 | Putative transcription initiation factor iib |
Schmidtea mediterranea | mk4.008667.00 | Putative transcription initiation factor iib |
Schmidtea mediterranea | mk4.035531.00 | Putative transcription initiation factor iib |
Schmidtea mediterranea | mk4.011787.00 | Putative transcription initiation factor iib |
Schmidtea mediterranea | mk4.003212.00 | Putative transcription initiation factor iib |
Schmidtea mediterranea | mk4.008957.00 | Putative transcription initiation factor iib |
Schmidtea mediterranea | mk4.010754.00 | Putative transcription initiation factor iib |
Schmidtea mediterranea | mk4.001961.00 | Putative transcription initiation factor iib |
Toxoplasma gondii | TGME49_292000 | hypothetical protein |
Toxoplasma gondii | TGME49_292010 | transcription initiation factor IIB |
Theileria parva | TP02_0202 | transcription initiation factor TFIIB, putative |
Trichomonas vaginalis | TVAG_071030 | transcription initiation factor iib, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
CELE_W03F9.5 | Caenorhabditis elegans | embryonic arrest | wormbase |
CELE_W03F9.5 | Caenorhabditis elegans | embryonic lethal | wormbase |
YPR086W | Saccharomyces cerevisiae | inviable | yeastgenome |
PBANKA_0202900 | Plasmodium berghei | Slow | plasmo |
TGME49_292010 | Toxoplasma gondii | Probably essential | sidik |
TGME49_292000 | Toxoplasma gondii | Probably essential | sidik |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.